Antifungal susceptibility of 84 Candida species isolated from oral cavity among college students

ObjectiveTo explore the susceptibility of Candida species isolated fromoralcavity to common antifungal agents among college students.MethodsThe broth microdilution antifungal test was used for the susceptibilities of 84 Candida strains to fluconazole,ketoconazole,fluorocy to sine and amphoteric in Band minmium inhibitory concentration(MIC) was used for the evaluation.ResultsThe geometric mean of susceptibility for the Candida species to the four antifungal agents were 3.175,0.07,0.272,and 0.43 mg·L^-1,respectively;the resistant rates were 8.3%,9.5%,7.1%,and 8.3%, respectively.There were significant differences in resistance bewteen Candida albicans and Candida non-albicans to ketoconazole and amphoteric in B(P<0.05).Three Candida species were resistant to 2 or more antifungal agents at the same time.ConclusionThe reexist resistant and cross resistant strains in Cadida species in oralcavity among college students,especially for Candida non-albicans.