Protective effect of anthocyanidins on retinal photochemical damage in rats

ObjectiveTo investigate the relationship between the protective effect of anthocyanin-rich extract from black rice(BRACs)on retinal photochemical damage(RPD)and anti-oxidative ability of anthocyanin.MethodsSixty SpragueDawley rats were randomly divided into control group,1ight group,and BRACs group.The retinal morphology was observed with light(hetatoxylin eosin staining)and transmission electron microscope.The concentration of malondialdehyde(MDA) and the activities of antioxidases in blood from eye socket were measured.ResultsLight exposure caused retina damage of varying degrees and increased MDA concentration to 8.82 nmol/mL and superoxide dismutase(SOD)to 27.08 U/mL (P<0.05),but decreased the level of glutathione S-transferase(GST)to 24.96 U/mL(P<0.05).Compared to light group, the retinal structure was normal in BRACs group;the concentration of MDA decreased to 6.85 nmol/ml(P<0.05);the activities of SOD,glutathion peroxidase,and GST increased to 28.90,433.69,and 34.75 U/ml,respectivity(P<0.05).ConclusionBRACs can effectively prevent the retina from photochemical damage via its anti-oxidative effect in rats.