Serum p16 and p21 protein expression among people living in Bama county of Guangxi

Objective To examine serum p16 and p21 protein expression among people living in Bama county,Guangxi Zhuang Autonomous Region,and to study the relationship between longevity and p16 and p21 protein.Methods Two hundred and one healthy individuals from longevity villages of Bama county were selected as the case group and another 119 healthy individuals from Nandan county as the control group.The levels of p16 and p21 protein expression were measured with enzyme-linked immunosorbent assay(ELISA).Results The levels of p16 and p21 protein of the case group were significantly lower than those of the control group(P < 0.01).The levels of p16 and p21 of different age categories and gender of the case group were all significantly lower than those of the control group.Conclusion The levels of p16 and p21 protein expression are much lower in individuals from longevity villages than in those from other areas,suggesting that longevity might be associated with lower expression of p16 and p21 protein.