Antifungal susceptibility of oral Candida species among drug abusers

ObjectiveTo examine the antifungal susceptibility of oral Candida species among drug abusers and to provide reference for treatment of candidasis in clinic.MethodsTotally 75 oral Candida species were tested for susceptibility of amphotericine B(Amb),5-flurocytosine(5-FC),fluconazole(FCZ),and ketonazole(KETO)with microdilution antifungal susceptibility test recommended by National Committee for Clinical Laboratory Standards(NCCLS).ResultsThe resistant rate of 75 oral Candida species from drug abusers for Amb,5-FC,FCZ,and KETO was 0,4%,8%,and 13.3%, respectively.The crosswise resistant rate of the strains for FCZ and KETO was 8%.The resistant rates of non-Candida albicans to FCZ(23.5%)and KETO(43.2%)were higher than those of Candida albicans with a significant difference.But the resistant rates to 5-FC and Amb were not significantly different for the two Candidas groups.ConclusionThe susceptibility of oral Candida species from drug abusers for Amb and 5-FC is higher than that of FCZ and KETO.Among the oral Candida species from drug abusers,both Candida strains resistant to FCZ,KETO,5-FC and Candida strains resistant crossw ise to FCZ and KETO are prevalent.Besides,the resistant rate and crossw ise resistant rate of non-Candida albicans to FCZ and KETO is higher than those of Candida albicans.