Effect of Liuhuang mixture on insulin sensitivity in insulin resistance rats

Objective To investigate the effects of traditional Chinese medicine-Liuhuang mixture on rat insulin resistance(IR) induced by dexamethasone (Dex).Methods IR rat model was induced with Dex and the interaction of Liuhuang mixture and rosiglitazone was administered to the rats.The effects of Liuhuang mixture on blood glucose,serum concentration of fasting insulin (FINS) and insulin sensitive index (ISI) were determined in the model rats.Results Liuhuang mixture lowered 2-hour blood glucose (2hBG) after oral glucose tolerance test and FINS,and improved ISI.Conclusion In the experiment with IR rat model,Liuhuang mixture can enhance insulin sensitivity.