Impact of peroxide-activated receptor gene polymorphism on effects of compound coarse grains dietary intervention among people with dyslipidemia

Objective To evaluate the effects of multiple nutritional dietary intervention on serum lipid profiles and physical indexes in a hyperlipidemia population and to study the relationship between peroxisome proliferator-activated receptor γ2(PPARγ2)Pro12/Ala12 genetic polymorphism and multiplex nutritional dietary intervention for making individual measures of hyperlipidemia prevention.Methods Totally 911 community adults(aged ≥45 years)with hyperlipidemia were recruited from Nanjing city and assigned into an intervention group(n=445)and a control group(n=466)and the participants in the intervention group were administered a compound nutritional intervention.The genotypes of PPARγ2 Pro12/Ala12 of the intervention group were determined with polymerase chain reaction-restriction fragment length polymorphism(PCR-RELP)technique and the susceptibilities to the intervention of the participants were compared.Results For the participants of the intervention group,both body mass index(BMI)and waist-hip ratio(WHR)decreased distinctly and blood lipid profiles were obviously improved compared to those of at the beginning of the intervention and those of the control group after the one-year compound nutritional intervention(all P<0.05).The lipid-lowering efficacy rate of the intervention group was 91.70%(408/445)and that of the control group was 15.45%(72/466),with a statistically significant difference(P<0.001).Among the participants in the intervention group,the proportions of PPARγ2 Pro12/Ala12 genotype were 89.21%(397/445)for PP,10.34%(46/445) for PA,and 0.45%(2/445) for AA.The hyperlipemia individuals with PA genotype were more susceptive to the dietary intervention than those with PP genotype and the total cholesterol in the participants with Ala12/X genotype decreased significantly(P<0.05).Conclusion The results show that multiplex dietary intervention can improve BMI,WHR,blood lipid profiles,blood glucose,and blood pressure in hyperlipidemia population.Analysis of genetic polymorphism suggests that different PPAR γ2 genotypes have different impacts on the effects of coarse grain dietary intervention in hyperlipidemia population.