Association of heparanse and syndecan-1 with human recurrent spontaneous abortion

ObjectiveTo explore the expressions of heparanase(HPSE) and syndecan-1 in the patients with recurrent spontaneous abortion and their relationships with recurrent spontaneous abortion.MethodsReal-time fluorescent quantitative reverse transcription polymerase chain reation(RT-PCR) was used to detect mRNA of HPSE and syndecan-1 in 35 normal pregnant women and 28 patients with recurrent spontaneous abortion in Datong municipality.Then we analyzed the relationship between the expressions of HPSE and syndecan-1 and recurrent spontaneous abortion.ResultsThe HPSE expression rate(85.71%,30/35) increased significantly in the normal pregnant group compared to that in the spontaneous abortion group(57.14%,16/28)(P<0.05); but syndecan-1 mRNA expression was significantly lower in normal group(54.28%,19/35) than that in spontaneous abortion group(82.14%,23/28)(P<0.05).The upregulation of HPSE was correlated with the downregulation of syndecan-1(r=-0.386, P<0.01).ConclusionLower expression of HPSE in human recurrent spontaneous abortion influences the degradation of extracellular matrix,results in the overexpression of syndecan-1 and restraint of the implantion of embryo,and leads to spontaneous abortion.