Prevalence and risk factors of human papilloma virus infection among women in Chengde city

Objective To investigate the prevalence and risk factors of cervical human papilloma virus (HPV) among adult community women in Chengde municipality of Hebei province and to provide evidences for the prevention of HPV infection and cervical cancer.Methods During January 2013 and January 2016,4 250 female local residents aged 18-69 years were recruited from 8 counties and 3 districts in Chengde municipality and surveyed with a questionnaire interview,thin prep cytologic test (TCT) and HPV DNA genotyping;then vaginoscopy,biopsy and pathological examination were performed among the participants identified with HPV 16/18 infection,atypical squamous cells-undetermined significance (ASCUS),atypical glandular cells (AGC),and more severe manifestations.Logistic regression analy-sis was adopted to analyze risk factors of HPV infection.Results Of the women,819 had HPV infection and the infection rate was 19.27%,with the top five infection rates for high-risk HPV types of 16,58,52,39,and 51. HPV infection rate was increased with the severity of cervical intraepithelial neoplasia (CIN) and the HPV infection rate was 100% in the participants with cervical cancer. The participants less than 20 years old showed the highest HPV infection rate of 21.74% and those aged 30 to 49 years and above 60 years had higher infection rate than the women of other age groups. Smoking,having first sex at younger age,with the education of high school or below,and with uterine cervical contact bleeding and uterine cervical columnar ectopy were risk factors of HPV infection; while condom use for contraception and having the knowledge about cervical cancer and HPV infection were protective factors of HPV infection.Conclusion HPV infection is closely related to CIN and cervical cancer among the women in Chengde city and screening and control of HPV infection could effectively prevent the occurrence of cervical cancer in the population.