Relationship between glycemic control and medication treatment in patients with type 2 diabetes mellitus in Jiangsu province

Objective To assess the relationship between medication treatment and glycemic control in patients with type 2 diabetes mellitus (T2DM) in Jiangsu province and to provide evidences for the control of T2DM.Methods We conducted a cross-sectional survey with stratified cluster sampling in Changshu city and Huai'an and Qinghe district of Huai'an city in Jiangsu province between December 2013 and January,2014.Totally 15 037 T2DM patients who were registered in the National Basic Public Health Service and administered with drug therapy were recruited in the three regions and all the patients received a questionnaire interview,laboratory tests and physical examinations.Results Of the 15 037 patients,12 318 (81.9%) took single oral hypoglycemic agent;1 728 (11.5%) took single insulin;and 991 (6.6%) adopted oral hypoglycemic agents plus insulin.The drug therapy for T2DM differed significantly by gender,education level,marital status,living region,residential address,smoking,alcohol drinking,course of T2DM,body mass index (BMI),and whether having central obesity,hyperlipidemia,diabetic complication,and family history of diabetes among the patients (P<0.01 for all).The proportion of the patients with the glycated hemoglobin Alc (HbA1c) reaching the national control standard was 32.5% and the proportion of glycemic control reaching the national control standard was 34.7%,25.4%,and 17.7% for the patients administered with single oral hypoglycemic agent,single insulin,and oral hypoglycemic agents plus insulin,respectively.The results of multivariate unconditional logistic regression analysis showed that the glycemic control rate for the patients taking single insulin and oral medication combined with insulin was 0.679 time (95% confidence interval95%CI:0.599-0.770) and 0.465 time (95%CI:0.388-0.558) lower than those taking single oral hypoglycemic agent after adjusting for all the potential confounders mentioned above.Conclusion The rate of medication treatment is high among T2DM patients in Jiangsu province,especially among the patients with single oral hypoglycemic agent,but the rate of glycemic control is still low.