Rlationship between mannose-binding protein P54 allele polymorphisms and susceptibility to pulmonary tuberculosis

  Objective  To explore the association between the genetic polymorphisms of mannose-binding protein(MBP)P54 allele and susceptibility to pulmonary tuberculosis.

  Methods  126 cases and 201 controls were collected.Acase-control study was conducted.Polymerase chain reaction with sequence-specific primers(PCR-SSP)was carried out in the polymorphism in MBPgene.Information on related risk factors of tuberculosis was collected by using a pre-tested questionnaire.Univariate and multivariate logistic analyses were conducted with SPSS software package.

  Results  The vaccinal vestige, BCGimmunization and familial traits were the risk factors of tuberculosis.Frequency of wildness, mutantheterozygote and homozygote of MBP-54 was difference in cases and controls.The univariate analysis demonstrated that MBP-54 G/Ahomozygote genotypes occurred more frequently in the men cases than controls, with crude OR(95 %CI)being 4.721(1.463~15.236).After adjusting three related environmental factors(vaccinal vestige, BCGimmunization and familial traits)in the multivariate logistic analyses, the MBP-54 G/Ahomozygote genotypes were still significantly overrepresented in men cases, with adjusted OR(95 %CI)being 7.304(1.722~30.983).

  Conclusion  MBP-54 genotypes might be associated with the susceptibility to pulmonary tuberculosis.