Surveillance on antibiotic resistance and extend-spectrum beta-lactamase of clinical Escherichia coil

  Objective   To observe the antibiotic resistance trend of clinical isolated Escherichia coil; the different drug resistance in the community acquired infection and hospital patient; the prevalence of partly strains producing Extended Spectram B-lactamases(ESBLs)in Qingyuan district.

  Methods   The sensitivity of 244 Escherichia coil to 20 antibiotics were tested by MicroScan AutoScan-4 and ESBLs were identified by disc agar diffusion method.

  Results   Forthree years the sensitivity rate of imipenem and piperacilin/tazobactam firmly kept on higher than 90%, and that of amikacin, cefoxitin, ceftazidime was higher than 70%.The resistance rate of cefotaxime in 2003 was significantly higher than that in 2001(χ²=7.86, P < 0.05).The resistance rates of ceftazidime, cefazoline, cefotaxime, ceftriax one and ciprofloxacin were gradually raised in the strains isolated from community acquired infection, hospital patient and ICU(P < 0.05 or 0.01), The rate of strains producing ESBLs was 30.8%, 46.5%, 85.7% respectively.(χ²=9.08, P < 0.05).The resistance rate of cefepime (72.2%)was significantly higher than that of ceftazidime(40.7%)in strains producing ESBLs(χ²=, P < 0.01), the resistance rate of other third-Cef was higher than 70%.

  Conclusion   There was a significant relation between the high drug resistance rate and the rate of strains producing ESBLs, which was gradually raised in the strains isolated from community acquired infection, hospital patient, and ICU.The high rate of strains producing ESBLs in community acquired infection should be considered severely.