Effects of pyrethroids on adenylyl cyclases and cyclic adenosine monophosphate of striatum in male rats

  Objective   To study the influences of deltamethrin(DM)and permethrin(PM)on cyclic andenosine monophosphate(cAMP)of Striatum and adenylyl cyclases(AC)of Striatum and Cortex in rats.

  Methods   Different doses of permethrin and deltamethrin carried in salad oil were administered to rats by oral administration for ten days, then the contents of AC protein in Striatum and Cortex were determined by the method of immunohistochemistry.And the level of cAMP was detected by the method of radioimmunoassay.

  Results   The levels of cAMP in the striatum and AC in the cortex were remarkably inhibited by DM and PM.

  Conclusion   Pyrethroids could significantly reduce the level of cAMP in the striatum and AC in the cortex.