Objective To assess the interaction between G894T (Glu298Asp)mutation of endothelial nitric oxide synthase (eNOS) gene and overweight in premature coronary heart disease(P-CHD).
Methods Hospital-based case-control study was used. The newly-diagnosed CHD patients were recruited as the subjects. The 132 CHD patients diagnosed before ageless than or equal to 55 years old for male and 65 years old for female were appointed as the P-CHD and the case group, other 172 CHD patients as the control group. Polymerase chain reaction with Ban Ⅱ restriction enzyme digestion was performed to detect the G894T mutation.
Results There was a positive interaction between G894T mutation and overweight in P-CHD. The synergy index (S)was 1.45, the relative excess risk due to interaction(RERI)was 1.32, and the attributable proportion due to interaction(AP)was 25.06%.After adjusting sex, smoking, alcohol drinking, waist-hipratio, serum triglyceride, serum total cholesterol by logistic regression, there was also positive interaction between G894T mutation and overweight in P-CHD. The S was 1.43, RERI was 2.76, AP was 27.21%.
Conclusion The interaction between G894T mutation of eNOS gene and overweight had a positive effect on the P-CHD in this studied population.
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