Objective To study the antitumor activities of folic acid.Folic acid are dealed with human gastric cancer cell line SGC-7901 in vitro.
Methods By means of four approaches as follows: cell proliferation cur veanalysis, MTT assay and cell cycle analysis by FCM.
Results After treatment with 375, 750 and 1 875 nmol/L, folic acid selectively inhibited the activity and function of SGC-7901.There are apoptotic peaks in cell cycle analysis by FCM and apoptosis rate reached 33.1%.
Conclusion The effects of folic acid on human embryo muscle sinew cells were slightly, which indicated that folic acid had no bad effects on normal cell, but inhibited tumor cell.