Relation between morning sickness and iodine nutrition, pituitary-thyroid function during early pregnant stage

  Objective   In order to reveal the effects of morning sickness on pituitary-thyroid function.

  Methods   To collect urine and vein blood of early pregnant women(12-14 weeks)and marriage examination women in the Women and Children Hospital of Shenzhen.Iodine in urine was determined by As(Ⅲ)-Ce ⁴⁺ catalytic spectrophotometry to measure serum iodine, Automated Chemiluminescence System was used to test FT₄、FrT₃ and sTSH.

  Results   Serum iodine(G)of 35 pregnant women who had morning sickness was 61.2 g/L, urine iodine was 152.1 g/L, FT₄ was 14.42 pmol/L, FrT₃/FT₄ WAS 0.346, sTSH was 3.78 mU/L.All of them were obviously lower or higher than those of non-morning sickness and non-pregnant group(p < 0 01).Urine iodine of morning sickness group < 100 g/L was 20%, and sTSH > 5 0 mU/L was 8.6%.Correlation was found between serum iodine and FT₄, sTSH in morning sickness group except for non-pregnant group(r=0.654 and -0.354, P < 0.01 and P < 0.05).

  Conclusion   Coordination impact was found between metabolism of iodine nutrition and descent of pituitary-thyroid function during early pregnancy, which should be paid attention to.