Relationship between DMT1 gene variation and Iron deficiency anemia in childbearing age women

  Objective  To investigate the association between single nucleotide polymorphism of relations of IVS4+44 locus on Divalent metal transporter-1(DMT1)gene and iron deficiency anemia in Beijing region.

  Methods  82 IDA patients(18~45 years old)were selected as case group and 94 nor mal populations as control.For all subjects the gene polymorphism at DMT1IVS4+44 locus was analyzed by PCR-RFLP method, and the SF and Hb levels were detected.

  Results  The heterozy gotes(+/-)genotype and homo zygotes(+/+)were both detected in the subjects.In control group the frequency of(+/-)genoty pe and(+)allele was 28.7 and 14.4, lower than Pauline L.Lee's report and Thomas Kelleher's report.In case group the frequency of(+/+), (+/-)geno type and(+)allele was 2.4, 19.5 and 12.2, without significantly different from control.The oddsration of(+/-) & (+/+)genotype was 0.70(0.35, 1.39).There was not significant difference fr om SF and Hb levels between different genotypes in case group and control group.

  Conclusion  There was not appar ent association betw een DMT1 gene IVS4+44 locus variation with IDA, SF level and Hb level.Fur ther studies are needed.