A clinical efficacy trial of different kinds of recombinant hepatits B vaccines,Chinese Hamster Ovary cell HB vaccine and Yeast HB vaccine

4 batches of Chinese Hamester Overy cell(CHO)derived vaccine(Institute of Changchun Biological Products,10ug/dose)and 2 batches of yeast derived vaccind(YDV:Amgen,10ug/dose,Merck,5ug/dose)were administered to 370 children by 0,1,6 schedule.After vaccination(T7,T12),the antibody positive tates of all groups were above 90% and declined slowly afterwards.At the twelfth month from the first dose,the anti-HBs level of Amgen group was significantly higher than these of other vaccines groups.However,the levels of Merck and CHO-A group were significantly lower than that of other vaccines groups at T24.The results showed that the anti-HBs response of CHO vaccine was similar to that of yeast vaccine.