RAD51 135G ＞ C polymorphism and risk of breast cancer: a meta-analysis

Objective To explore the association between RAD51 codon 135G ＞ C polymorphism and the risk of breast cancer（ BC） by systematically reviewing the original studies. Methods A comprehensive search was conducted to identity all case-control studies on RAD51 codon 135G ＞ C polymorphism and BC risk. Meta-analysis was applied with Review Manager 5. 0. 24 software for calculation of pooled odds ratio（ OR） value and 95% confidence interval（ 95% CI） of BC. Results From the 15 case-control studies selected for this meta-analysis,a total of 12 717 BC cases and 12 088 controls were included. Compared with the wild-type homozygote GG,the pooled OR（ 95% CI） of CC,GC,and（ GC + CC） genotypes of RAD51 codon 135G ＞ C for BC were 1. 45（ 1. 13,1. 86）,0. 95（ 0. 75,1. 20）,and 1. 08（ 0. 91,1. 27）, respectively. Conclusion Homozygote CC for RAD51 codon 135G ＞ C polymorphism is associated with an increased risk of BC. Furthermore,heterozygote GC and（ GC + CC） for RAD51 codon 135G ＞ C genetic polymorphism might do not increase the risk of BC.