Association of comorbidity of metabolic syndrome and diabetes mellitus with cardiovascular disease

Objective To investigate the relationship between metabolic syndrome（ MS） complicated with diabetes mellitus（ DM） and cardiovascular disease（ CVD） and to provide reference data for the prevention and control of CVD.Methods By means of prospective study method,a baseline survey was carried out among 8 685 participants aged≥ 35 years selected with stratified cluster sampling from Jiangsu province from April 1999 to June 2004. During the period from March 2006 to November 2007,a total of 3 887 participants completed the 5 year follow-up. Logistic regression and Cox regression were used in the analyses. Results During the follow-up period,116 subjects developed CVD among 3 887 participants. After adjustments for age,gender,and other CVD risk factors and MS components,only DM and blood pressure were associated with CVD,with the adjusted risk ratio（ aRR）（ 95% confidence interval95% CI） of 3. 54（ 2. 28-4. 96） and 2. 58（ 1. 55-4. 29）. The cumulative incidence of CVD was 1. 53%,4. 47%,9. 17%,and 13. 30% for the participants without MS or DM,with only MS,with only DM,and with both DM and MS,respectively. After adjusting for sex,age and other risk factors,compared with the healthy,the participants with only MS,with DM,and with both MS and DM had the aRR of 1. 96,4. 11,and 7. 10,respectively. After adjusting for gender,age,and other risk factors,compared to the participants with only MS,the aRR（ 95% CI） for CVD of the participants with both MS and DM was 2. 23（ 1. 65- 3. 29）,while the aRR（ 95% CI） of for the DM participants with MS was 1. 36（ 0. 85- 2. 03） compared those without MS. The cumulative incidences of CVD among hypertensive participants with and without DM at the baseline survey were 16. 0% and 4. 0%,and those of normtensive participants were 7. 5% and 1. 1%. After adjustment for baseline age,gender,other CVD risk factors,and components of MS,the hypertensive participants with DM had a 3. 31 times higher risk of CVD than those without DM and the normtensive participants with DM had a 6. 02 times risk of CVD than those without DM. Conclusion MS patients with DM have higher risk for CVD and the control of DM can reduce the incidence of CVD among MS patients.