Abstract: The norovirus GII.P17_GII.17 is a new variant strain emerging in Asia from 2014 through 2015, which was contributed to the epidemics involving much more sufferers, larger scales, and stronger severity than norovirus GII.4. In recent years, there have been many researches on structure of capsid protein and receptor and evolution mechanism of norovirus GII.P17_GII.17 with the application of self-assembled virus like particles (VLPs). These researches provide a theoretical basis for the prevention and control of relevant diseases, such as acute diarrhea, and the development of vaccine.