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摘要: 今年是世界艾滋病流行以来的第30个年头,全球艾滋病流行与防治形势都发生了巨大的变化。自上世纪九十年代中期高效联合抗逆转录病毒治疗(highly active antiretroviral therapy,HAART)技术应用以来(1),成千上万的艾滋病病人得到有效治疗,特别是近5年,抗病毒治疗药物在发展中国家广泛使用,治疗病人数目迅速增长,2007-2009年2年间,全球接受抗病毒治疗的病人数几乎翻倍,达到约525万人(2),病人的生命得以延长,艾滋病引发的相关死亡大幅度下降。
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[1] Ho D.Time to hit HIV,early and hard[J].N Engl J Med,1995,333:450-451. [2] WHO,UNAIDS,UNICEF.Towards universal access:scaling up pri-ority HIV/AIDS interventions in the health sector-progress report 2010[R].Geneva:WHO,2010. [3] 卫生部疾病控制局.中国艾滋病防治-疫情、策略与重点[C].第六届中国艾滋病防治国际合作项目经验交流会.北京;2011. [4] 中国疾病预防控制中心性病艾滋病预防控制中心.中国艾滋病防治工作进展[C].I2011年全国艾滋病性病丙肝防治工作年会.广州; 2011. [5] Zhang F,Dou Z,Ma Y,et al.Effect of earlier initiation of antiretro-viral treatment and increased treatment coverage on HIV-related mortality in China:a national observational cohort study[J].Lancet Infect Dis,2011,11:516-524. [6] Granich R,Crowley S,Vitoria M,et al.Highly active antiretroviral treatment as prevention of HIV transmission:review of scientific ev-idence and update[J].Current Opinion in HIV and AIDS,2010,5:298-304. [7] Quinn TC,Wawer MJ,Sewankambo N,et al.Viral load and hetero-sexual transmission of human immunodeficiency virus type 1.Rakai Project Study Group [J].N Engl J Med,2000,342:921-929. [8] Donnell D,Baeten JM,Kiarie J,et al.Heterosexual HIV-1 transmis-sion after initiation of antiretroviral therapy:a prospective cohort a-nalysis[J].Lancet,2010,375:2092-2098. [9] Das M,Chu PL,Santos GM,et al.Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco[J].PLoS ONE,2010,5:e11068. [10] Fang CT,Hsu HM,Twu SJ,et al.Decreased HIV transmission after a policy of providing free access to highly active antiretroviral thera-py in Taiwan[J].J Infect Dis,2004,190:879-885. [11] Montaner JSG,Lima VD,Barrios R,et al.Association of highly ac-tive antiretroviral therapy coverage,population viral load,and yearly new HIV diagnoses in British Columbia,Canada:a population-based study[J].Lancet,2010,376:532-539. [12] Grant RM,Lama JR,Anderson PL,et al.Preexposure chemoprophy-laxis for HIV prevention in men who have sex with men[J].N Engl J Med,2010,363:2587-2599. [13] Karim QA,Karim SSA,Frohlich JA,et al.Effectiveness and safety of tenofovir gel,an antiretroviral microbicide,for the prevention of HIV infection in women[J].Science,2010,329:1168-1174. [14] Mocroft A,Ledergerber B,Katlama C,et al.Decline in the AIDS and death rates in the EuroSIDA study:an observational study[J].Lancet,2003,362:22-29. [15] Johnston KM,Levy AR,Lima VD,et al.Expanding access to HAART:a cost-effective approach for treating and preventing HIV [J].AIDS,2010,24:1929-1935. [16] Granich RM,Gilks CF,Dye C,et al.Universal voluntary HIV testing with immediate antiretroviral therapy as a strategy for elimination of HIV transmission:a mathematical model[J].Lancet,2009,373:48-57. [17] The Joint United Nations Programme on HIV/AIDS.Ten million deaths and 1 million new HIV infections could be averted if coun-tries meet HIV treatment targets[R].Geneva:WHO,2010.
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