ApoB基因多态性与HCV感染易感性关系

刘燕; 杨静静; 喻荣斌; 王昊鹏; 王洁; 崔倩; 邓小昭; 张云

doi:10.11847/zgggws-2011-27-05-14

ApoB基因多态性与HCV感染易感性关系

Relationship between the polymorphism of apoliprotein B gene and hepatitis virus C infection

摘要

摘要: 目的探讨载脂蛋白B(ApoB)基因单核苷酸多态性C-2488T和G-4154A在病例组与对照组的分布及与HCV感染的遗传易感性关联。方法采用聚合酶链式反应-限制性片段长度多态性(PCR-RFLP)方法,对190例HCV感染者和398例对照组人群进行C-2488T和G-4154A多态性检测,比较不同基因型与HCV感染易感性关系。结果 G-4154A位点病例组和对照组基因型为GG、GA、AA分别有160、27、3例和364、32、2例,基因型频率分别为84.2%、4.2%、1.6%和91.5%、8.0%、0.5%,差异有统计学意义(P<0.05);病例组和对照组等位基因为A、G分别有347、33例和760、34例,差异有统计学意义(P<0.05);C-2488T位点病例组和对照组基因型为CC、CT、TT分别有176、14、0例和357、40、1例,基因型频率分别为92.6%、7.4%、0.0%和89.7%、10.1%、0.3%,差异无统计学意义。结论江苏省汉族人群ApoB基因多态性改变可能与HCV感染的遗传易感性有关。

Abstract: Objective To investigate the rela tionship between two functional polymorphisms of the A poB gene and in fection of hepatitis C virus(HCV).Methods PCR restriction fragment length polymorphism(PCR-RFLP)technique was used to analyze the geno type of the A poB gene in 190 antiHCV positive hemodialysis patients(cases)and 398 anti-HCV negative hemodialysis patients frequency-matched to the cases by age and sex.Results The geno type frequency of GG,GA,and AA of G4154A was 84.2%,4.2%,and 1.6% for the cases and 91.5%,8.0%,and 0.5% for the controls with significant differences between the two groups(P<0.05 for all).The number of potients with A allele and G allele were 347 and 33 for the cases and 760 and 34 for the controls with significant difference bewteen the two groups.There was no significant difference in geno type frequency of C-2488T polymorphism bewteen cases and controls.Conclusion The results reveal that the polymorphism of the A poB gene may be associated with the susceptibility to HCV infection.

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