Abstract: Objective To assess the disease burden of alcohol dependence disorder and its distribution among people aged more than 15 years in the urban and rural of Guangxi Zhuang Autonomous Region.Methods The method of the Global Burden of Disease(GBD)study was used to calculate the disability-adjusted life years(DALYs)of alcohol dependence disorder based on the epidemiological survey data of mental disorders in the urban and rural of Guangxi Zhuang Autonomous Region in 2007 and the retrospective sample survey data on death in 2006.Results The DALYs of alcohol depend-ence disorder in the residents were 1.45 per 1 000 people in 2007,with the lost due to years of life lost(YLL)of 0.05 per 1000 people and lost to disability(YLD)of 1.40 per 1000 people.The DALYs of alcohol dependence disorder were signficantly higher in the males(21.83 per 1000 people)than in the females(0.14 per 1000 people)and higher in the rural area (1.95 per 1000 people)than in the urban area(0.65 per 1000 people).The DALYs of alcohol dependence disorder was higher in the people aged 30-69 years and the highest in the people aged 60-69 years.Conclusion Rural resident,smale,the middle aged and the elderly people are the key groups for prevention and rehabilitation of alcohol dependence disorder in Guangxi and measures should be taken to prevent the disability caused by alcohol dependence disorder.