Abstract: Objective To examine the prevalence of mood disorders among residents in Guangxi Zhuang Autonomous Region.Methods From July 2007 to December 2007,a total of 18 219 residents aged more than 15 years were randomly selected from 6 prefecture-level cities and 10 counties with stratified multi-stage cluster sampling.All subjects were investigated by face-to-face interviews.The Chinese Version of Composite International Diagnostic Interview(CI=DI 3.0)provided by the Chinese Center for Disease Control and Prevention was used as the screening tool and the diagnoses were made according to the International Classification of Diseases-10th edition.Results The general current prevalence and the general lifetime prevalence of mood disorders in the residents were 4.50‰ and 6.70‰.The risk factors of mood disorders were female gender,minority,and divorce based on logistic regression analyses.The general current prevalence was higher in the women than in the men(odds ratioOR=1.47,95% confidence intervalCI=:1.05-2.23)and higher in the minorities than in the Han(odds ratioOR=1.30,95% CI=:1.06-1.76).The divorsed individuals show ed higher current and lifetime prevalence of mood disorders.Conclusion Mood disorder is one of the most common mental disorders among the residents in Guangxi.The minority and divorsed individuals had a higher prevalence of mood disorder.Major deperession should be most concerned for the mood disorders among the residents.