Objective  To analyze the prevalence and influencing factors of depression and anxiety among people living with HIV/AIDS (PLWHA) in Yunnan province.

  Methods  Convenient sampling method was used to select 410 PLWHA in Kunming city and Longchuan county of Yunnan province. The depression and anxiety of the participants were measured with Patient Health Questionnaire Depression Module (PHQ-9) and Generalized Anxiety Disorder Scale (GAD-7), and the degree of social support was measured with social support scale. Multivariate logistic regression was used to analyze influencing factors of depression and anxiety of the participants.

  Results  Among the participants, the total score for social support was 28.05 ± 7.23. The overall prevalence of depression and anxiety were 81.5 % and 70.7 % (79.7 % and 68.0 % for the males, 85.7 % and 77.3 % for the females). The prevalence of depression and anxie-ty were the highest among the participants aged 35 – 44 years (P < 0.05). The participants not receiving treatment and having more symptoms or signs of HIV infection were more likely to suffer from depression and anxiety; the participants with lower subjective support score had a higher risk of anxiety.

  Conclusion  The prevalence of depression and anxiety are high among people living with HIV/AIDS in Yunnan province; strengthening early antiviral therapy and providing more social support and care are helpful for improving their mental health conditions.