Abstract: Diabetes, as one of the most prevalent chronic metabolic diseases in the world, is a specifically lifestyle-related disease pertaining to diet and exercise. Whether the use and presence of trans-fatty acids in the diet exerting adverse effects on metabolic health has been the hot subject of the recent research. Recently, epidemiological and laboratory studies have found that intake of trans-fatty acids can increase the risk of the diabetes, but due to inconsistencies in the research design and method, it is not yet possible to draw a firm conclusion. The study reviews researches on the association of trans-fatty with diabetes for providing references to developing dietary recommendations and future researches.