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王凤英, 唐慧玲. 金华市男男性行为艾滋病患者生存时间与影响因素分析[J]. 中国公共卫生, 2019, 35(12): 1633-1636. DOI: 10.11847/zgggws1124417
引用本文: 王凤英, 唐慧玲. 金华市男男性行为艾滋病患者生存时间与影响因素分析[J]. 中国公共卫生, 2019, 35(12): 1633-1636. DOI: 10.11847/zgggws1124417
Feng-ying WANG, Hui-ling TANG. Survival time and related factors among MSM with HIV/AIDS in Jinhua city[J]. Chinese Journal of Public Health, 2019, 35(12): 1633-1636. DOI: 10.11847/zgggws1124417
Citation: Feng-ying WANG, Hui-ling TANG. Survival time and related factors among MSM with HIV/AIDS in Jinhua city[J]. Chinese Journal of Public Health, 2019, 35(12): 1633-1636. DOI: 10.11847/zgggws1124417

金华市男男性行为艾滋病患者生存时间与影响因素分析

Survival time and related factors among MSM with HIV/AIDS in Jinhua city

  • 摘要:
      目的  分析浙江省金华市男男性行为(MSM)艾滋病病毒感染者/艾滋病患者(HIV/AIDS)确证后的生存时间及其影响因素,为有效开展MSM人群艾滋病防治工作提供科学依据。
      方法  采用回顾性队列研究方法,对金华市2002 — 2018年的MSM人群HIV/AIDS的生存时间及影响因素进行分析,对流行病学相关特征进行描述性分析,用寿命表法计算生存率,用Cox回归模型分析生存时间的影响因素。
      结果  1 326例MSM人群HIV/AIDS中,接受抗病毒治疗1 129例(85.14 %)。1 272例完成了最终随访(95.93 %),平均随访时间为(40.78 ± 31.26)个月,总随访时间为54 083.90个月,发生艾滋病相关死亡21例。平均生存时间为185.10(95 % CI = 177.47~192.73)个月。第1、5、10、15年生存率分别为98.53 %、98.02 %、93.12 %、93.12 %。多因素Cox回归模型分析结果显示,艾滋病死亡相关的危险因素包括未抗病毒治疗(比抗病毒治疗,HR = 22.753,95 % CI = 8.510~60.832)、确证时为AIDS(比HIV 感染者,HR = 7.820,95 % CI = 2.141~28.560)、基线CD4+T 淋巴细胞计数(CD4)< 250个/μL(比 ≥ 250个/μL,HR = 5.307,95 % CI = 1.425~19.759)。
      结论  金华市MSM人群HIV/AIDS治疗效果好,早发现早治疗是延长MSM患者生存时间的关键,实施“扩大检测、发现就治疗”防控策略意义重大。

     

    Abstract:
      Objective  To analyze the survival time and its related factors among men who have sex with men (MSM) with human immunodeficiency virus infection/acquired immunodeficiency syndromes (HIV/AIDS) in Jinhua city of Zhejiang province.
      Methods  The data for the retrospective cohort study were extracted from National AIDS Prevention and Control Information System. The participants were 1 326 MSM with HIV/AIDS living in Jinhua city at the time being registered from 2002 through 2018 and all the participants were followed up to December 31, 2018. Life table method was applied to calculate the survival rate and Cox proportion hazard regression model was used to analyze factors related with survival time.
      Results  Of all the participants, 1 129 (85.14%) received antiretroviral therapy (ART) and 1 272 (95.93%) completed the final follow-up. The total follow-up time was 54 083.90 person-months, with an average follow-up time of 40.78 ± 31.26 person-months and totally 21 died of AIDS related diseases by the end of the follow-up. The average survival time was 185.10 months (95% confidence interval 95% CI: 177.47 – 192.73) and the survival rate for 1, 5, 10, and 15 years after the incidence registration were 98.53%, 98.02%, 93.12%, and 93.12%, respectively. Multivariate Cox proportion hazard regression model indicated that not receiving ART (hazard risk HR = 22.753, 95% CI: 8.510 – 60.832), diagnosed as AIDS at the registration (HR = 7.820, 95% CI: 2.141 – 28.560), with a lower baseline CD4+T cell count (< 250 cells/μl) (HR = 5.307, 95% CI:1.425 – 19.759) were risk factors for decreased survival compared with receiving ART, diagnosed as HIV infection at the registration, and a higher baselin CD4+T cell count (≥ 250 cell/μl).
      Conclusion  The outcome of ART is good among the MSM with HIV/AIDS in Jinhua city and early diagnosis and treatment are the key measures to prolong the survival time of MSM with HIV/AIDS.

     

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