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刘仕俊, 张艳, 姜彩霞, 徐珏, 裘欣, 罗军, 刘冰. 高血压患者可干预危险因素与全死因死亡及心脑血管死亡关系研究[J]. 中国公共卫生, 2023, 39(9): 1102-1107. DOI: 10.11847/zgggws1141233
引用本文: 刘仕俊, 张艳, 姜彩霞, 徐珏, 裘欣, 罗军, 刘冰. 高血压患者可干预危险因素与全死因死亡及心脑血管死亡关系研究[J]. 中国公共卫生, 2023, 39(9): 1102-1107. DOI: 10.11847/zgggws1141233
LIU Shijun, ZHANG Yan, JIANG Caixia, XU Jue, QIU Xin, LUO Jun, LIU Bing. Associations of modifiable risk factors with all-cause and cardiovascular disease deaths: a linkage study among adult community hypertension patients in Hangzhou city[J]. Chinese Journal of Public Health, 2023, 39(9): 1102-1107. DOI: 10.11847/zgggws1141233
Citation: LIU Shijun, ZHANG Yan, JIANG Caixia, XU Jue, QIU Xin, LUO Jun, LIU Bing. Associations of modifiable risk factors with all-cause and cardiovascular disease deaths: a linkage study among adult community hypertension patients in Hangzhou city[J]. Chinese Journal of Public Health, 2023, 39(9): 1102-1107. DOI: 10.11847/zgggws1141233

高血压患者可干预危险因素与全死因死亡及心脑血管死亡关系研究

Associations of modifiable risk factors with all-cause and cardiovascular disease deaths: a linkage study among adult community hypertension patients in Hangzhou city

  • 摘要:
      目的  了解高血压患者可干预危险因素与全死因死亡及心脑血管死亡的关系,为高血压的预防控制提供参考依据。
      方法  收集浙江省杭州市各社区卫生服务机构2015年1月1日 — 12月31日纳入基本公共卫生服务健康管理的51438例高血压患者的相关数据,随后与死因监测平台进行匹配,追踪截至2021年2月28日的死亡结局,采用多因素Cox比例风险回归模型分析高血压患者可干预危险因素与全死因死亡及心脑血管死亡的关系。
      结果  截至2021年2月28日,高血压患者全死因死亡和心脑血管死亡分别为2365和842例,死亡比例分别为4.60%和1.64%;51438例高血压患者中,具有0、1、2和 ≥ 3项可干预危险者分别为3926例(7.63%)、20392例(39.64%)、20292例(39.45%)和6828例(13.28%);在调整了性别、年龄、居住地、是否流动人口和是否合并糖尿病等混杂因素后,未控制血压高血压患者全死因死亡风险和心脑血管死亡风险分别为控制血压高血压患者的1.39和1.52倍,现在吸烟高血压患者全死因死亡风险和心脑血管死亡风险分别为现在不吸烟高血压患者的1.21和1.24倍,未每日锻炼高血压患者全死因死亡风险和心脑血管死亡风险分别为每日锻炼高血压患者的1.52和1.73倍,具有1、2、≥ 3项可干预危险因素高血压患者全死因死亡风险和心脑血管死亡风险分别为具有0项可干预危险因素高血压患者的1.53和1.69倍、1.97和2.32倍、2.35和2.94倍,肥胖高血压患者全死因死亡风险为非肥胖高血压患者的0.84倍。
      结论  高血压患者可干预危险因素越多,其全死因死亡风险和心脑血管死亡风险越高。

     

    Abstract:
      Objective  To analyze correlations of modifiable risks with all-cause deaths and cardiovascular disease (CVD) deaths in hypertension patients.
      Methods  Comprehensive data of 2015 on 51 438 community hypertensive patients aged 35 – 85 years were extracted from the management information system of Essential Public Health Services and were linked to individual records of mortality in the datasets of death registry system up to February 28, 2021 in Hangzhou municipality, Zhejiang province. Cox proportional regression model was used to estimate hazard risks of all-cause and CVD deaths associated with modifiable risk factors of the mortalities.
      Results  By the end of study period, totally 2 365 all-cause and 842 CVD deaths were observed among the participants and the mortality ratios were 4.60% and 1.64%, respectively. Of the 51 438 hypertensives, 3 926 (7.63%), 20 392 (39.64%), 20 292 (39.45%), and 6 828 (13.28%) were assessed as having none, one, two, and three and more modifiable risk factors of CVD. The results of Cox proportional regression analysis showed that after adjusting for gender, age, living region, migration, and diabetes, the hypertensives being lack of good blood pressure control (systolic blood pressure SBP of ≥ 140 mmHg/diastolic blood pressure (DBP) of ≥ 90 mmHg at three measurements not in the same day) were at significantly increased risks of all-cause death (hazard risk HR = 1.39) and CVD death (HR = 1.52) compared to those under effective blood pressure control (SBP < 140 mmHg/DBP < 90 mmHg); the hypertensives being current smoker had significantly increased risks of all-cause death (HR = 1.21) and CVD death (HR = 1.24) contrasting to nonsmoking hypertensives; the hypertensives not having daily physical exercise were at significantly increased risks of all-cause death (HR = 1.52) and CVD death (HR = 1.73) in comparison to those reporting daily physical exercise; the results also revealed significantly increased risks of all-cause death (HR = 1.53, HR = 1.69, and HR = 1.97) and CVD death (HR = 2.32, HR = 2.35,and HR = 2.94) for the hypertensives with one, two, and three modifiable risk factors compared to those without any modifiable risk factor; while, the obese hepertensives had a significantly decreased risk of all-cause death (HR = 0.84) compared to the non-obese hypertensives.
      Conclusion  The risks of all-cause and CVD death increased with the number of modifiable risk factors among adult community hypertension patients.

     

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