Abstract: To study the effects of cadmium on frucose and transferrin in seminalplasma from occupationally exposed workers,the general conditions of workers were investigated with the questionnaire.The determination of frucose was carried out using the methods that WHO recommended,and transfery in was assayed by using kit.The results showed that the amount of fructose and transferrin was significantly lower in the exposed group than that in the control group(P<0.05,P<0.01),but no significant difference was found in the content of fructose and transferr in anlong different blood cadmium groups.There was a decreasing trend of the concentrations of fructose and transferrin as the increase of seminal plasma cadmium concentration.The content of transferrin in seminal plasma was reduced significantly by prolonged cadmium exposure period(P<0.01),but the content of ructose among different cadmium exposure period showed no significant difference.Comelation analysis indicated that a negatively conelative relationship between the fmctose,transferrin in the seminal plasma and the rate of malformation sperm(P<0.05).These findings suggested that the secretive functions of the testicular cell can be affected by occupational cadmium exposure.