Abstract: In order to investigate the relationship between insulin resistance(IR) and risk factors of coronary heart disease(CHD),a case-case study was conducted.There were 48 acute myocardial infarction patients,70 coronary angiographycally defined CHD and 53 vasospastic angina being brought into the study.Among them,88 insulin sensitive index ≤P₂₅ and/or serum insulin lever≥P₇₅ were defined as insulin resistance group,other 83 were defined as non-insulin resistance group.Uni-variable analysis indicated that cigarette smoking and overweight were associated with IR with Odds Ratio of 2.29(1.06～4.98) and 1.89(0.98～3.36) respectively Means comparison showed that body mass index(BMI) and numbers of cigarette consumption per-day in IR group were significantly higher than that of non-IR group.Logistic regression analysis indicated that BMI and cigarette smoking being selected into equation.It seems that cigarette smoking and overweight associated with IR in CHD patients.