Abstract: In order to find out the multiple risk factors of high density lipoprotein cholesterol disorder, we have undertaken case-control study of 211 volunteers with questionnaire, diet survey and laboratory examination to get the information. It was found that the prevalence of HDL-CH disorder was 42. 18%, 34. 55% in male and 50. 50% in female. Smoking, obesity, poor labour and motion, high diastolic pressure, high level intake of fat and meat, and low level intake of vegetables were risk factors of HDL-CH disorder.