Abstract: To measure the resistant state of N.gonor rhoeae and the distribution of resistant plasmids in Zhanjiang,and then probe their relationship.98 go nococcal epidemic strains obtained from 1998 through 1999 in Zhanjian.(Guangdong)were detected their susceptibilities to ten antibiot ics by disk diffusion method;the plasmids were extracted by alkaline lysis technique,and then analysis the distribution of resistant plasmids.The results showed that 6.12 percent strains were sensitive to all 10 kinds of antibiotics, 48.96 percent strains were resistant to 3 and more kinds of antibiotics.Four kinds of different molecular weight plasmids were found.7.4kb and 4.2 kb plasmids were more prevalent,the percentages were 59.16% and 67.32%.There were 12 types of plasmid profiles.The types of 7.4kb+4.2kb and 39.5kb+7.4kb +4.2kb were primary,being accounted for 38.76%.The trends of multi-drug resistance of N.gonorr hoeae in Zhanjiang were severe;the resistant plasmids were 7.4kb"Asian type" plasmids,the percentages were accounted for 59.16%.But the relationship between the resistant plasmids and their resistance had to be investigated as further.