Abstract: The effect of OPV NIDS for 8 rounds of 4 times from 1993 to 1998 in Shandong province was analyzed comparatively,The results showed that the vaccinated target children were increased and the loss-chance vaccinated children were decreased year by year.The vaccine coverage rates were higher among children of 1 to 4 age groups than those of 0-age group,which meant that children of 0-age group were still important target population for OPV vaccination though they could make compensation for their vaccination in the future immunization activities.The effect and quality,including the reliability and accuracy of the reporting data of NIDs vaccination,were also much better than those of routine immunization.All above indicated that the OPV supplemental vaccination on the basis of the routine immunization was still recommended as the first-choice strategy for the following poliomyelitis eradication activities.