Abstract: Objective The genetic epidemiological studies on systemic lupus erythematosus(SLE)suggested that the disorder has some genetic component.Methods Complex segregation analysis was performed with their nuclear families through 215 Chinese probands using POINTERS software.Results The result presented that analysis of entire samples allowed rejection of no transmission model,and no rejection of polygenic model as well as major gene model(including dominant and recessive models).Conclusion SLE could be a multifactorial disease with Multi-Major-Locus.More attention to the subtypes or phenotypes and their genetic models of SLE should be paid in future.