Abstract: Objective To investigate the distribution of cases with Hemorrhagic Fever with Renal Syndrome(HFRS),murine-like animals and related insects and to explore the determinants of the disease.Methods The data of HFRS were collected from the cases reporting system in Shenzhen.The risk factors were analysed by case-control study.Results The morbidity rate was 0.10 pre 100 000 from 1999 to 2000.Shenzhen Futian district 81.8%,temporary populatoin occuppied 63.63%.The ratio of male to female is 10:1.Eighty one point eighty one percent occured in Janary to April.Associations were observed between the outdoor living (χ²=10.12,OR=16),high density of mice around the living places(χ²=4.51,OR=12),there exited stastical significance.Six hundred and twenty-five murine-like animals captured were indentified to 11 species,of 58.88% of which were Rattus norvegicus.The positive rate of Hantavirus antigen was 0.81%,the positive rate of antibody was 7.17%,GMT of the antibody was 1:54.45.The rate of infection is 10.81%,and the positive rate of the antigen to HFRS was 1.37%.All positive samples were from Rattus norvegicus.The rates of mouse carrying tick,flea,gamasid,jigger were 7.02%,10.06%,17.08%,7.40% respectively.The main host was R.sladen,R.flavipectus,R.losea,R.sladen respectively.Flea was Xenopsylla cheopis.Tick was identified to 2 species belonging to 2 genera,87.21% was Ixodes granulatus.Gamasid was identified to 3 species belonging to 2 genera,91.94% was Laelaps echidninus.Jigger was identified to 6 species belonging to 4 genera,27.21% was Walchis Xishacnsis.Conclusion There are rattus-related HFRS epidemic foci in Shenzhen,which belongs to lower morbidity district.