Abstract: Objective To understand the know ledge level of AIDS prevention,prevalence rate of HIV,and to change the attitudes and behaviors in drugusers in Hainan Province.Methods Drug users were interviewed through questionnaire about AIDS knowledge,and to be intervened through training,playing video and propag anda.Results Most of the drugusers are unmarried,accounting for 72.96%,and the unemployed for 65.36%.Their ages are from 15 to 30 years old,and the average time of drug use is 2.98 years.The proportion of intravenous drug users is 33.85%,among which 24.70% shared syringes and needles with other drugusers.The positive rate of anti-HIV,anti-HCV,HBsAg and syphilis were 0.20%,29.69%,22.85% and 7.03% respectively.The AIDS know ledge in drug users increased for 1.34 to 24.16 percent after the intervention for one year.Conclusion It was imperative to pursue wide education of AIDS prev ention and the harm of druguse in drug users to reduce HIV infection.