Abstract: Objective To investigate the major psychological problems of middle school students and the methods and effects of intervention.Methods Four typical schools were selected,and the second grade students in middle school and the second grade students in high school were investigated with SCL-90.They were asked to list the first 20 psychological problems,then compared them between the middle school students and high school students who lived in school.Additionally,the psychological guidance was given to the intervented group for 3 months.Results The major psychological problem was that the students had great pressure and they could not be understood.To some extent,the psychological problem was improved after the intervention guidance.Conclusion More attention should be paid to the student's psychological problems to reduce students pressure.The psychological guidance was effective,but it should be persisted in.