Abstract: Objective To explore the effect of perinatal lead intervention on the development of newborn's nervous behavior.Methods The inter vention epidemiological investigation was proceeded with the perinatal lead exposure by using Ebselen,and the umbilical blood lead was detected by atomic absorption method and the umbilical blood selenium was detected by double ways fluorescent photometer and the development of ner vous behavior(NBNA) on day 26-28 of new born was evaluated by using double blind method.Results The navel blood lead of intervention group was 0.34μmol/L,which was lower than the control group remarkably (0.5μmol/L),the blood selenium,zinc and GSH-Px were all higher than the control(P_av<0.01),the content of LPO was lower than the control(P<0.01).The percent of NBNA>35 in intervention group was 65.8%,which is obviously better than the control(P<0.01).Conclusion The perinatal lead intervention has obviously promotion on alleviating the lead tox in of newborn,improving the level of trace nutrients,enhancing the ability of anti-oxidation and protecting the normal development of new born's intelligence.