Abstract: Objective To approach the effects of air pollution on immunofunction of human bodies in order to provide scientific basis for improv ing existent and preventing diseases.Methods Children aged 6-8 years from severe and mild polluted area with- out occupat ional ex posure and administering antibiotics in the latest three months were selected and IgM,IgM,IgA,IgE in their sera were detemined by ELISA.Results Immunoglobin were greatly affected by external environment.The IgA and IgM level of the children was much lower and IgG and IgE was higher in the severe area than that in the mild one(P<0.01 or P<0.05).There was no differences in immunoglobin level between both male and female children(P>0.05).Conclusion Air pollution markedly influenced the immunofunction.It was an important factor for damaging immunofunction and inducing immunog lobin level changes and increasing incidence of respiratory diseases.