Abstract: ObjectiveTo study the effects of temperature on calcium-activated potassium channels(KCa)in hypothalamic neurons of new-born SD rats.MethodsThe data was recorded by adopting inside-out configuration of patch-clamp technique.ResultsAs the temperature increased,peak conductance and open probability(P₀)of the channel increased greatly.When the temperature was at 37℃ and 39℃,the Q₁₀ of the conductance and P₀ was 1.63、1.86 and 2.83、3.56.The time constants had temperature-dependent reductions.ConclusionThese results indicated the calcium2activated potassium channels in hypothalamic neurons had high temperature sensitivity,more researches on it may be helpful to elucidate the mechanism of temperature regulation of animals.