Abstract: ObjectiveTo study the mechanism of the effect of PLA₂ on the damage of brain tissues after combined soman and hypoxia injury.MethodsThe changes in cAMP,ATP,ADP,AMP,PLA₂,Evans blue,water contents of brain tissue were studied in the Wister after the combined soman and acute hypoxia injury with microtitration,albumin labelled with Evans blue,RIA,and electron micropy for 12,24,48 hours.ResultsThe changes of the content of cAMP,ATP,ADP,AMP, PLA₂,Evans blue were sig nificantly higher at soman intoxicated group athy poxia than at soman in toxicated group and control group athypoxia.ConclusionThe damage became more severe at combined soman and hypoxia injury,compared with soman or hypoxia injury,also the damage appeared earlier and more severe.It shows alteration of brain energy metabolism,activation of PLA₂,activation of cAMP and their correlation with neuronal damage.