Abstract: Objective GSH,Vi-tC and DMPS were given to rats to study the effects on the renal toxicity induced by chronic exposure to cadmium.Methods Fifty SD rats were divided into five groups at random.Four groups rats were given subcutaneous injections of 5μmol/kg CdCl2 and another group rats were injected with 0.9% NaCl for eleven weeks.The urine sample were collected after the last injection.From the twelfth week,the sceond group rats were intraperitonealy(ip)injected with 0.9% NaCl,the third group rats were ipinjected with 1mmol/kg GSH,the fourth group rats were ipinjected with 4mmol/kg Vi-tC and the fifth group rats were ip injected with 0.2mmol/kg DMPS.After two weeks,urinary samples were collected again.NAG activities,protein and cadmium contents were determined in the urinary samples.Results Urinary NAG activities,contents of urinary protein and cadmium in the Cd-administered groups were increased significantly,and they were different from the control group.After the administration of GSH,Vit-C and DM PS,urinary NAG activities and the contents of urinary protein was decreased sig nificantly as compared with that before the administration of the three compounds,and with that of the animals given cadmium alone.The urinary cadmium contents were decreased significantly except the animals that were administered with DMPS.Conclusion Cadmium administration resulted in the renal injury,and GSH,Vi-tC and DMPS played the antagonistic effects on the renal toxicity of cadmium.