Abstract: Objective To study the effect of laminaria japonica-extract(LJE)on antiperoxidation and hemorheology.Methods The variation of SOD、MDA and GSH-PX in the blood of treated mice(administrated with LJE for one month) and control mice was quantitated with biochemical technique.The levels of blood-lipids and blood viscosity in rats serum of test group(administered with high lipid food combined with LJE for one month)and control group(administered with only high lipid food)was detected.Results The level of SOD in the plasma of treated mice were significantly higher than the normal group,and the level of MDA was much lower than the normal mice and the level of GSH-PX in the blood of mice had no significant difference between LJE group and normal group.The experimental results of LJE on antilipemicim and Hemorheology showed that the levels of blood-lipids and blood viscosity in treated rats were significantly lower than the control rats.Conclusion LJE had some effect on antiperoxidation and blood viscosity.