Abstract: Objective To comprehened the resistant state of shigella and plasmid profiles of shigella isolated in Honghe area.Methods the susceptibilityes to thirteen antibiotics 66 shigella epidemic strains obtained from hospitals were detected by disk diffusion method,the plasmid were extracted by Kado.Results One hundrend percent strains were resistant,94、45 percent strains were resistand to 3 or more kinds of antibiotics.There were 36 types of antibioti-cresistant profiles,much dispersing.Eight kinds of different weight molecular plasmid were found.350Md and 120Md plasmid were more prevalent,the percentages were 42.42% and 45.45%.There were 12 type of plasmid profiles.The type of 350Md and 120Md were primary,accounting for 68.18%.Conclusion In comparison with antibiotic-resistant profiles,the same PP-type strains existed different of identical antibiotic-resistant profiles.The relationship between the pp-type and antibiotic-resistant profiles had to be invest igated as further.Combing reports of literature,120Md was est imated as invasive plasmid of shigella.It indicated that 350Md were R plasmid of Hong he district.