Abstract:
Objective The effects of selenium on oxygen free radical inducing injury of rat cerebral mitochondria were investigated.
Methods The oxygen free radicals(OFRs)injured cerebral mitochondria induced by Fe
2+-Cys in vitro were exposed to 5.0×10
-5-5.0 mol/L.Na
2SeO
3 and the changes of injured mitochondria swelling,membrane fluidity,MDA levels and mitochondria structures were observed.
Results Low Se concentration(5.0×10
-4-5.0×10
-2 mol/L)can inhabit the injury of rat cerebral mitochondria induced by oxygen free radicals while high Se concentration(0.5-5.0 mol/L) cause toxicity and both are with a relationship of dose-dependent response.
Conclusion Low Se concentration is helpful to delay aging and against nervous disease.