狂犬病毒CTN-1v株毒种的不良反应与免疫学效果研究

Studies on side effect and immunolical effect of CTN-IV Stain

摘要: 目的观察CTN-1v株毒种的不良反应及免疫学效果.方法选择20例健康者接种应用CTN-1v株毒种制备的狂犬病疫苗,观察接种者的不良反应进行中和抗体测定.结果接种者的不良反应率为35%(7/20),中和抗体阳转率为100%,免疫后14天中和抗体水平平均为13.08IU/ml(5.83～22.16IU/m1).结论 CTN-1v株毒种,不良反应轻微而且免疫原性良好,可在短时间产生较高水平的中和抗体.

Abstract: Objective To observe the immunological effect and side effect of CTN-1v strain.Methods Detection of neutralizing antibody and observation of side effect is carried in 20 volunteers who are vaccinated by CTN-1v vaccine.Results Rates of side effect are 35%(7/20),the rates of positive antibody are 100%(20/20),and the level of neutralizing antibody was 13.08 IU/ml(5.83-22.16 IU/ml).Conclusion CTN-1v strain is characterized by side effect slightly and good immunolonicity,large production of antibody.