寻常型银屑病单纯病例研究

魏生才; 李明; 高敏; 张学军; 王再兴; 杨森

doi:10.11847/zgggws2002-18-12-24

寻常型银屑病单纯病例研究

Case-merely Study on Psoriasis Vulgaris

摘要

摘要: 目的研究寻常型银屑病环境因素与HLA-DQA₁*0104、DQA₁*0201和DQA₁*0501等位基因的交互作用.方法采用单纯病例研究方法,调查176例寻常型银屑病患者环境因素,用PCR-SSP方法检测HLA-DQA₁*0104、DQA₁*0201和DQA₁0501等位基因,对寻常型银屑病环境因素与HLA-DQA₁*0104、DQA₁*0201和DQA₁*0501等位基因交互作用进行研究.结果 (1)HLA-DQA₁*0104等位基因与精神紧张呈现交互作用(P=0.0383,OR=0.41).(2)HLA-DQA₁*0201等位基因与饮酒(P=0.0451,OR=0.52)、手术(P=0.0332,OR=3.93)存在交互作用.(3)HLA-DQA₁0501等位基因与接种疫苗(P=0.0145,OR=12.0)存在交互作用.结论 HLA-DQA₁*0104、DQA₁*0201和DQA₁*0501等位基因能加强或减弱环境因素发生银屑病的危险性.

Abstract: Objective To study the HLA-DQA₁ *0104,DQA₁ *0201,DQA₁ *0501 alleles and environmental factors interaction in psoriasis vulgaris.Methods Using case-merely study,176 psoriatics were investigated.The HLA-DQA₁ *0104,DQA₁*0201 and DQA₁*0501 alleles were examined by PCR-SSP.Results (1)The HLA-DQA₁*0104 allele and stress were interaction in psoriasis(P=01038 3,OR=0141).(2)The HLA-DQA₁*0201 allele,drinking(P=0.045 1,OR=0.52)or operation(P=0.033 2,OR=3.93)were interaction in psoriasis.(3)The HLA-DQA₁*0501 allele and vaccination(P=0.014 5,OR=12.0)were interaction in psoriasis.Conclusion The HLA-DQA₁*0104,DQA₁*0201 and DQA₁*0501 alleles improved or reduced risk possibility of environmental factors in psoriasis.

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