Abstract:
Objective To investigate the relationship between expression of CD44v6 and prognosis of colorectal carcino ma(CRC).
Methods The expression of CD44v6 in 120 CRC cases was detected by Streptavidin-Peroxidase immunohisto chemical technique.
Results The positive expression rate of CD44v6 in CRC was 31.7% (38/120).The positive expression of CD44v6 in CRC was significantly associated with lymph nodes metastasis and Dukes stage(P < 0.05).The positive expression rate of CD44v6 in CRC withly mph nodes metastasis was significantly higher than that without lymph nodes metas tasis; the positive expression rate of CD44v6 was gradually increasing when Dukes stage deeping.CD44v6 expression was correlated to survival time of CRC cases(P < 0.01).
Conclusion CD44v6 expression in CRC is associated with Dukes stage, lymph nodes metastasis and survival time of CRC cases.CD44v6 is a prognostic factor of CRC probably.