内蒙古东部地区居民食管癌危险因素分析

Analysis on heritability and risk factors of eastern resident in Inner Mongolia

摘要:
目的了解食管癌遗传影响程度及发病危险因素。
方法使用遗传流行病学方法及病例对照研究方法。
结果 (1) 食管癌一级亲属遗传度为(38.9±9.5)%。(2)食管癌的危险因素为饮酒年限(OR=5.4081, 95%CI=3.8927~6.7921)、吸烟年限(OR=2.8159, 95%CI=2.2671~3.1267)、黑便(OR=9.1724, 95%CI=7.7860~10.8963)、精神刺激史(OR=6.6015, 95%CI=5.0274~7.2164)、经济状况恶化(OR=4.7932, 95%CI=3.1362~5.7233)。
结论食管癌具有明显的家庭集聚性; 不良行为习惯及负性生活事件与食管癌的发生存在关联。

Abstract:
Objective To determine the affection degree of heritability and incidence risk factors of esophageal carcinoma in the eastern inner Mongolia area.
Methods The heredity epidemiology method and case-control study were performed.
Results The heritability of the first degree relative of esophageal carcinoma was(38.9±9.5)%.The risk factors for esophageal carcinoma included:time limit of drinking liquor(OR=5.408 1, 95% CI=3.892 7~6.792 1).time limit of smoking(OR=2.815 9, 95% CI=2.267 1~3.126 7), melena(OR=9.172 4, 95% CI=7.786 0~10.896 3)psycho-stimulatory history(OR=6.601 5, 95% CI=5.027 4~7.216 4)less-develop factor(OR=4.793 2, 95% CI=3.136 2~5.723 3).
Conclusion There was family assemblage in esophageal carcinoma obviously.There was correlative relation between esophageal carcinoma and bad habit and negative living events in the eastern inner Mong olia area.