慢性磷中毒患者血清中8种物质检测分析

李溥; 岑荣光; 罗毅; 莫兴菊; 韦绍英

doi:10.11847/zgggws2005-21-07-22

慢性磷中毒患者血清中8种物质检测分析

Analysis on laboratory examination for serum of eight materials in patients with chronicity phosphorus poisoning

摘要

摘要:
目的了解慢性磷中毒患者血清中8种物质含量变化, 探讨其在慢性磷中毒发病机制中的作用。
方法应用放射免疫法对患者血清透明质酸(HA)、IV型胶原(IV-C)、胆酸(CG)、肿瘤坏死因子(TNF)、转化生长因子-α(TGFα)、白细胞介素-1(IL-1)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)进行测定和分析。
结果慢性磷中毒组与对照组比较HA、IV-C、CG、TGFα、IL-1、IL-6、IL-8明显升高(P < 0.01), 而TNF明显下降(P < 0.01);分层分析, 重度组与对照组比较, 差异有统计学意义(P < 0.01)。
结论慢性磷中毒患者血清中8种物质含量测定, 可以了解磷对机体的损害程度和范围, 对慢性磷中毒的防治具有重要指导作用。

Abstract:
Objective To investigate the serum levels of eight materials changes in patients and to understand their mechanism.
Methods Serum contents of hyaluronic(HA), type IV collagen(IV-C), cholalic acid(CG), tumor necrosis factor(TNF), transfor ming growth Factor-(TGF), interleukin-1(IL-1), interleukin-6(IL-6)and interleukin-8(IL-8)were detected by radioimmunoassay and were analyzed.
Results Compared with control the serum contents of HA, IV-C, CG, TGF, IL-1, IL-6 and IL-8 rose significantly(P < 0.01).while analyzed by delamination, there was marked difference between the serious group and control(P < 0.01).
Conclusion Radioimmuno assay detecting of the above-mentioned eight materials in patiens with chronicity phosphorus poisoning plays an impo rtant role in judging the range and degree of the body and in directing treatment and preventation.

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